走自己的路讓別人去說

研究介紹

本實驗室的研究工作以兩個在台灣相當重要的黃質病毒：日本腦炎病毒（JEV）以及登革病毒（DEN）為主。JEV經由蚊子感染人類，會引起急性腦炎，有相當高的致死率。DEN會引起登革熱、或是較為嚴重的登革出血熱和登革休克症候群。黃質病毒的基因體為單股正向的RNA，能夠作出一個大蛋白質，經過切割後形成大約11個病毒結構性以及非結構性蛋白質。我們研究方向著重於這兩個病毒的分子生物學、病毒學、致病機轉、免疫學以及疫苗與藥物研發，目標是希望能瞭解病毒與宿主之間的相互關係。目前的工作重點在病毒免疫方面有：JEV擷抗Jak-Stat訊息傳遞的分子機制；DEN抑制干擾素誘發的機制；以及第一型干擾素所誘發的蛋白質抑制JEV/DEN感染的作用機制。在病毒複製方面有：研究內質網以及未折疊蛋白質反應在JEV和DEN複製過程中所扮演的角色；以及探討細胞因子在病毒生活史上可能扮演的角色。

精選論文

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   0. Chien, H-L., C.-L. Liao, and Y.-L. Lin*. 2011. The FUSE binding protein 1 interacts with untranslated regions of Japanese encephalitis virus RNA and negatively regulates viral replication. Journal of Virology 85: 4698-4706.
   0. Lin, K.-H.#, J.-J. Liang#, W.-I Huang, S.-Y. Lin-Chu, C.-Y. Su, Y.-L. Lee, J.-T. Jan, Y.-L. Lin*, Y.-S. E. Cheng, and C.-H. Wong*. 2010. In vivo protection provided by a synthetic new alpha-galactosyl ceramide analog against bacterial and viral infections in murine models. Antimicrobial Agents and Chemotherapy54: 4129-4136.
   0. Yu, C.-Y., R.-L. Chiang, T.-H. Chang, C.-L. Liao, and Y.-L. Lin*. 2010. The interferon stimulator mitochondrial antiviral signaling protein facilitates cell death by disrupting the mitochondrial membrane potential and by activating caspases. Journal of Virology 84: 2421-2431.
   0. Lin, R.-J., H.-P. Yu, B.-L. Chang, W.-C. Tang, C.-L. Liao, and Y.-L. Lin*. 2009. Distinct antiviral roles for human 2￠,5￠-oligoadenylate synthetase family members against dengue virus infection. Journal of Immunology 183: 8035-8043.
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   0. Chan, Y.-L., T.-H. Chang, C.-L. Liao, and Y.-L. Lin*. 2008. The cellular antiviral protein Viperin is attenuated by proteasome-mediated protein degradation in Japanese encephalitis virus-infected cells. Journal of Virology 82: 10455-10464.
   0. Lee, C. J., H. R. Lin, C. L. Liao, and Y.-L. Lin*. 2008. Cholesterol effectively blocks entry of flavivirus. Journal of Virology 82: 6470-6480.
   0. Chen, S. T., Y.-L. Lin, M. T. Huang, M. F. Wu, S. C. Cheng, H. Y. Lei, C. K. Lee, T. W. Chiou, C. H. Wong, and S. L. Hsieh*. 2008. CLEC5A is critical for dengue-virus-induced lethal disease. Nature 453: 672-676.
   0. Yu, C.-Y., Y.-W. Hsu, C.-L. Liao, and Y.-L. Lin*. 2006. Flavivirus infection activates XBP1 pathway of the unfolded protein response to cope with endoplasmic reticulum stress. Journal of Virology 80: 11868-11880.
   0. Lin, R.-J., B.-L. Chang, H.-P. Yu, C.-L. Liao, and Y.-L. Lin*. 2006. Blocking of interferon-induced Jak-Stat signaling by Japanese encephalitis virus NS5 through a protein tyrosine phosphatase-mediated mechanism. Journal of Virology 80: 5908-5918.
   0. Liu, W.-H., Y.-L. Lin, J.-P. Wang, W. Liou, R. F. Hou, Y.-C. Wu*, and C.-L. Liao*. 2006. Restriction of vaccinia virus replication by a ced-3 and ced-4-dependent pathway in Caenorhabditis elegans. Proc Natl Acad Sci USA 103: 4174-4179.
   0. Liang, P.-H., W.-C. Cheng, Y.-L. Lee, H.-P. Yu, Y.-T. Wu, Y.-L. Lin*, and C.-H. Wong*. 2006. Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis. Chem Bio Chem 7: 165-173.
   0. Chang, T.-H., C.-L. Liao, and Y.-L. Lin*. 2006. Flavivirus induces interferon-beta gene expression through a pathway involving RIG-I-dependent IRF-3 and PI3K-dependent NF-kB activation. Microbes and Infection 8: 157-171.